"Middlesex" by Jeffrey Eugenides
Loved everything about this book - from it being set in Michigan (my former home state) to following the three generations of the Stefanides family to hearing how Cal's life and self discovery unfold. I listened to the audiobook and understand that Middlesex (in addition to winning a Pulitzer) won an "Audi" award. I'm not surprised; the narrator was wonderful - so much so that I wonder if reading the paper book would have impacted my love of the story since I'd have to create the voices in my head.
I also enjoyed the historical fiction aspect, which I hadn't expected when I started the book. Bonus!